SI sus datos no sobrepasarán los 4000 caracteres Y está en SQL Server 2000 o nivel de compatibilidad de 8 o SQL Server 2000:
UPDATE [CMS_DB_test].[dbo].[cms_HtmlText]
SET Content = CAST(REPLACE(CAST(Content as NVarchar(4000)),'ABC','DEF') AS NText)
WHERE Content LIKE '%ABC%'
Para SQL Server 2005+:
UPDATE [CMS_DB_test].[dbo].[cms_HtmlText]
SET Content = CAST(REPLACE(CAST(Content as NVarchar(MAX)),'ABC','DEF') AS NText)
WHERE Content LIKE '%ABC%'